Calcium Sennoside.

Creating a niche of Calcium Sennoside. such as Calcium Sennoside, Senna Pod & Sennoside, Sennoside Senna Pod Extract, Senna Leaves Extract 20% Sennoside., Senna Extract Powder 7.5% BP, Sennosides Tablets and many more items at its best, with utmost quality.

Calcium Sennoside

Item Code: 101
Sennoside a&b usp.
  • Calcium Sennosides is biggest product commercially for Vijay food – India.
  • We have dedicated plant for production of Senna Extract, capacity to produce 4 MT Sennosides per Month
  • Senna leaf extracts standardized to 8%, 10%, 15%, 20% and 60% Calcium sennosides.

Active Pharmaceutical Ingredients:

  • Calcium Sennoside A&B 20%, 40% and 60% as per USP.
  • Calcium Sennoside A&B 20%, 40% and 60% as per BP.
  • Calcium Sennoside A&B 20%, 40% and 60% by HPLC
  • Sennoside 90% as per USP.
  • Leaf Powder contain more than 2% of Sennoside.
Other Information
  • Pay Mode Terms: L/C (Letter of Credit)
  • Port of Dispatch: Mumbai,Mundra.
  • Production Capacity: 5000kg.
  • Delivery Time: One week
  • Packaging Details: 25 Kg.Hdpe Drum.

Senna Pod & Sennoside

Item Code: 210

Offering Senna pod & Calcium Sennoside
  • Calcium Sennosides is biggest product commercially for Vijay food – India.
  • We have dedicated plant for production of Senna Extract, capacity to produce 4 MT Sennosides per Month
  • Senna leaf extracts standardized to 8%, 10%, 15%, 20% and 60% Calcium sennosides.


Active Pharmaceutical Ingredients:

  • Calcium Sennoside A&B 20%, 40% and 60% as per USP.
  • Calcium Sennoside A&B 20%, 40% and 60% as per BP.
  • Calcium Sennoside A&B 20%, 40% and 60% by HPLC
  • Sennoside 90% as per USP.
  • Leaf Powder contain more than 2% of Sennoside.
Other Information
  • Pay Mode Terms: L/C (Letter of Credit)
  • Port of Dispatch: Mumbai, Mundra.
  • Production Capacity: 5000kg.
  • Delivery Time: One week
  • Packaging Details: 25 Kg.Hdpe Drum.

Sennoside Senna Pod Extract

Sennoside Senna Pod Extract

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Item Code: 212

Sennoside Senna pod extract

  • Calcium Sennosides is biggest product commercially for Vijay food – India.
  • We have dedicated plant for production of Senna Extract, capacity to produce 4 MT Sennosides per Month
  • Senna leaf extracts standardized to 8%, 10%, 15%, 20% and 60% Calcium sennosides.


Active Pharmaceutical Ingredients:


  • Calcium Sennoside A&B 20%, 40% and 60% as per USP.
  • Calcium Sennoside A&B 20%, 40% and 60% as per BP.
  • Calcium Sennoside A&B 20%, 40% and 60% by HPLC
  • Sennoside 90% as per USP.
  • Leaf Powder contain more than 2% of Sennoside.


Other Information
  • Pay Mode Terms: L/C (Letter of Credit)
  • Minimum Order Quantity: 500 Kilogram
  • Port of Dispatch: Mumbai Mundra
  • Production Capacity: 5000kg
  • Delivery Time: Oneweek
  • Packaging Details: 25 Kg.Hdpe Drum.

 

Senna Leaves Extract 20% Sennoside.

Senna Leaves Extract 20% Sennoside.

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Item Code: 213


Senna leves extract 20% sennoside

  • Cassia Angustifolia Extract is biggest product commercially for Vijay food – India.
  • We have dedicated plant for production of Cassia Angustifolia Extract, capacity to produce 4 MT Sennosides per Month
  • Cassia Angustifolia Extract standardized to 8%, 10%, 15%, 20% and 60% Calcium sennosides.

Active Pharmaceutical Ingredients:

  • Cassia Angustifolia Extract A&B 20%, 40% and 60% as per USP.
  • Cassia Angustifolia Extract A&B 20%, 40% and 60% as per BP.
  • Cassia Angustifolia Extract A&B 20%, 40% and 60% by HPLC
  • Sennoside 90% as per USP.
  • Leaf Powder contain more than 2% of Sennoside.


Raw Senna Herb

  • Leaves of Different size grade.
  • Pods.

Senna Extract Powder 7.5% BP

Senna Extract Powder 7.5% BP

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Item Code: 218

Senna extract powder 7.5% bp.

Active Ingredient : Calcium Sennosides 10%, Calcium Sennosides 20% & Calcium Sennosides 40%

Common Name : Senna, Indian Senna, Tinnervelly Senna, Cassia Senna

Chemical Constituents and Components : Main chemical components are anthraquinone glycosides, sennosides, rhein, aloe-amine, kaempferein, iso-rhein, kaempferol, isormamnetin, myricyl alcohol, mucilage and flavonoids.

Action :
Sennosides: 1. It specifically influences large intestinal motility and show purgative action. 2. It influences both colon motility as well as colon secretion. 3. It shows good intestinal mucosa tolerance. 4. It significantly decreases net water and Na+ absorption and enhanced net K+ secretion.

Curing Diseases : 1. It is used in the treatment of constipation and act as purgative and laxative.
2. It is useful in indigestion, loss of appetite and obesity.
3. It is useful in hepatomegaly, spleenomegaly, jaundice and anaemia.
4. It is also useful in acne, ringworm affection and for inflammatory skin conditions.

Research Information : Cassia angustifolia extract is uaed as enema after abdominal operation. It regulates disordered funtion of gastrointestional tract abdominal operations. (Ref. Wang, M., Yan, S. and Wang, J., Clinical and experimental study on using Cassia angustifolia extract as enema after abdominal operation, PubMed, 1998 Sep; 18(9): 540-2)

Possible Combinations : Cassia angustifolia + citrus reticulate (weight loss)



Sennosides Tablets

Item Code: 106
We deliver Sennosides Tablets meeting all the Quality Standards.

Manufacture of Calcium Sennosides

Manufacture of Calcium Sennosides

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Item Code: 203

Manufacture of Calcium Sennosides

A.Short description of process :


Senna leaves are tested before and after grinding for Sennosides contents and are extracted with methanol.
The above methanolic extracts are collected and Calcium sennosides are separated by addition of Calcium Salt solution. The precipitated Calcium sennosides are centrifuged and washed with methanol & dried under vacuum. The dried Calcium sennosides are ground, tested and packed.

B.Process Control Test :

The following control parameters are monitored during manufacture :

  • PH of Aqueous suspension
  • Heavy metals
  • Residue on igination.
  • L.O.D
  • Assay

Senna Dry Extract.

Item Code: 103
Calcium Sennoside
  • Calcium Sennosides is biggest product commercially for Vijay food – India.
  • We have dedicated plant for production of Senna Extract, capacity to produce 4 MT Sennosides per Month
  • Senna leaf extracts standardized to 8%, 10%, 15%, 20% and 60% Calcium sennosides.


Active Pharmaceutical Ingredients:


  • Calcium Sennoside A&B 20%, 40% and 60% as per USP.
  • Calcium Sennoside A&B 20%, 40% and 60% as per BP.
  • Calcium Sennoside A&B 20%, 40% and 60% by HPLC
  • Sennoside 90% as per USP.
  • Leaf Powder contain more than 2% of Sennoside.

Other Information :

Pay Mode Terms: L/C (Letter of Credit)

Minimum Order Quantity: 500 Kilogram

Port of Dispatch: Mumbai Mundra

Production Capacity: 5000kg

Delivery Time: Oneweek

Packaging Details: 25 Kg.Hdpe Drum.

Sennoside

Item Code: 105
Sennoside
  • Calcium Sennosides is biggest product commercially for Vijay food – India.
  • We have dedicated plant for production of Senna Extract, capacity to produce 4 MT Sennosides per Month
  • Senna leaf extracts standardized to 8%, 10%, 15%, 20% and 60% Calcium sennosides.


Active Pharmaceutical Ingredients:


  • Calcium Sennoside A&B 20%, 40% and 60% as per USP.
  • Calcium Sennoside A&B 20%, 40% and 60% as per BP.
  • Calcium Sennoside A&B 20%, 40% and 60% by HPLC
  • Sennoside 90% as per USP.
  • Leaf Powder contain more than 2% of Sennoside.


Other Information

  • Pay Mode Terms: L/C (Letter of Credit)
  • Port of Dispatch: Mumbai, Mundra.
  • Production Capacity: 5000kg.
  • Delivery Time: Oneweek
  • Packaging Details: 25 Kg. HDPE Drum.

Sennosides (Senokot)

Sennoside
  • Calcium Sennosides is biggest product commercially for Vijay food – India.
  • We have dedicated plant for production of Senna Extract, capacity to produce 4 MT Sennosides per Month
  • Senna leaf extracts standardized to 8%, 10%, 15%, 20% and 60% Calcium sennosides.


Active Pharmaceutical Ingredients:


  • Calcium Sennoside A&B 20%, 40% and 60% as per USP.
  • Calcium Sennoside A&B 20%, 40% and 60% as per BP.
  • Calcium Sennoside A&B 20%, 40% and 60% by HPLC
  • Sennoside 90% as per USP.
  • Leaf Powder contain more than 2% of Sennoside.



Use Of Senna / Sennosides As Laxative

Use Of Senna / Sennosides As Laxative

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Item Code: 104

How much is usually taken? It’s best to follow the instructions on the label of over-the-counter senna products. Some doctors suggest an herbal extract in capsules or tablets providing 20–60 mg of sennosides per day. This can be continued for a maximum of ten days maximum. Use beyond ten days is strongly discouraged. If constipation is not alleviated within ten days, individuals should seek the help of a healthcare professional. Combination with herbal mint teas can help decrease cramping. Half the adult amount of senna can be safely used in children over the age of six.

Presentation:
Tablets: Enteric-Coated or Uncoated containing 37.5 to 90 mg of Calcium Sennosides equivalent to 7.5 to 18 mg of Hydroxyanthracene glucosides as Sennoside B per tablet

Powders: With or without other components like Isabgol, Cascara sagrada etc. containing raw powdered herb or Calcium Sennosides equivalent to 5 to 30 mg of Hydroxyanthracene glucosides as Sennoside B per dose

Liquids: Syrup or fluid extract with or without alcohol containing 5 to 30 mg of Hydroxyanthracene glucosides as Sennoside B per dose

Others: Also presented in the form of herbal teas, chocolate pieces

How to take:
Tablet--Swallow with liquid. If you can't swallow whole, chew or crumble tablet and take with liquid or food.
Liquid, granules--Drink 6 to 8 glasses of water each day, in addition to one taken with each dose.
Suppositories--Remove wrapper and moisten suppository with water. Gently insert larger end into rectum. Push well into rectum with finger.

When to take:
Usually at bedtime with a snack, unless directed otherwise.

If you forget a dose:
Take as soon as you remember.

What drug does:
Acts on smooth muscles of intestine wall to cause vigorous bowel movement.

Time lapse before drug works:
6 to 10 hours.

Don't take with:
Don't take within 2 hours of taking another medicine. Laxative interferes with medicine absorption.

Senna & Sennoside

Item Code: 209

Offering Calcium Sennoside

  • Calcium Sennosides is biggest product commercially for Vijay food – India.
  • We have dedicated plant for production of Senna Extract, capacity to produce 4 MT Sennosides per Month
  • Senna leaf extracts standardized to 8%, 10%, 15%, 20% and 60% Calcium sennosides.


Active Pharmaceutical Ingredients:

  • Calcium Sennoside A&B 20%, 40% and 60% as per USP.
  • Calcium Sennoside A&B 20%, 40% and 60% as per BP.
  • Calcium Sennoside A&B 20%, 40% and 60% by HPLC
  • Sennoside 90% as per USP.
  • Leaf Powder contain more than 2% of Sennoside.

Other Information

  • Pay Mode Terms: L/C (Letter of Credit)
  • Port of Dispatch: Mumbai, Mundra.
  • Production Capacity: 5000kg.
  • Delivery Time: One week
  • Packaging Details: 25 Kg.Hdpe Drum.

Senna Pod Extract

Item Code: 1002

Senna pod extract a+b


Active Ingredient : Calcium Sennosides 

Common Name : Senna, Indian Senna, Tinnervelly Senna, Cassia Senna

Chemical Constituents and Components : Main chemical components are anthraquinone glycosides, sennosides, rhein, aloe-amine, kaempferein, iso-rhein, kaempferol, isormamnetin, myricyl alcohol, mucilage and flavonoids.

Action : 
Sennosides: 1. It specifically influences large intestinal motility and show purgative action. 2. It influences both colon motility as well as colon secretion. 3. It shows good intestinal mucosa tolerance. 4. It significantly decreases net water and Na+ absorption and enhanced net K+ secretion.

Curing Diseases : 1. It is used in the treatment of constipation and act as purgative and laxative.
2. It is useful in indigestion, loss of appetite and obesity.
3. It is useful in hepatomegaly, spleenomegaly, jaundice and anaemia.
4. It is also useful in acne, ringworm affection and for inflammatory skin conditions.

Research Information : Cassia angustifolia extract is uaed as enema after abdominal operation. It regulates disordered funtion of gastrointestional tract abdominal operations. (Ref. Wang, M., Yan, S. and Wang, J., Clinical and experimental study on using Cassia angustifolia extract as enema after abdominal operation, PubMed, 1998 Sep; 18(9): 540-2)

Possible Combinations : Cassia angustifolia + citrus reticulate (weight loss)


Cassia Angustifolia Extract With Sennoside.

Cassia Angustifolia Extract With Sennoside.

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Item Code: 211

Offering Cassia Angustifolia Extract

  • Cassia Angustifolia Extract is biggest product commercially for Vijay food – India.
  • We have dedicated plant for production of Cassia Angustifolia Extract, capacity to produce 4 MT Sennosides per Month
  • Cassia Angustifolia Extract standardized to 8%, 10%, 15%, 20% and 60% Calcium sennosides.

Active Pharmaceutical Ingredients:

  • Cassia Angustifolia Extract A&B 20%, 40% and 60% as per USP.
  • Cassia Angustifolia Extract A&B 20%, 40% and 60% as per BP.
  • Cassia Angustifolia Extract A&B 20%, 40% and 60% by HPLC
  • Sennoside 90% as per USP.
  • Leaf Powder contain more than 2% of Sennoside.


Raw Senna Herb

  • Leaves of Different size grade.
  • Pods.

Sennoside Laxative

Item Code: 214
Sennoside laxative.

How much is usually taken? It’s best to follow the instructions on the label of over-the-counter senna products. Some doctors suggest an herbal extract in capsules or tablets providing 20–60 mg of sennosides per day. This can be continued for a maximum of ten days maximum. Use beyond ten days is strongly discouraged. If constipation is not alleviated within ten days, individuals should seek the help of a healthcare professional. Combination with herbal mint teas can help decrease cramping. Half the adult amount of senna can be safely used in children over the age of six.

Presentation:
Tablets: Enteric-Coated or Uncoated containing 37.5 to 90 mg of Calcium Sennosides equivalent to 7.5 to 18 mg of Hydroxyanthracene glucosides as Sennoside B per tablet

Powders: With or without other components like Isabgol, Cascara sagrada etc. containing raw powdered herb or Calcium Sennosides equivalent to 5 to 30 mg of Hydroxyanthracene glucosides as Sennoside B per dose

Liquids: Syrup or fluid extract with or without alcohol containing 5 to 30 mg of Hydroxyanthracene glucosides as Sennoside B per dose

Others: Also presented in the form of herbal teas, chocolate pieces

How to take:
Tablet--Swallow with liquid. If you can't swallow whole, chew or crumble tablet and take with liquid or food.
Liquid, granules--Drink 6 to 8 glasses of water each day, in addition to one taken with each dose.
Suppositories--Remove wrapper and moisten suppository with water. Gently insert larger end into rectum. Push well into rectum with finger.

When to take:
Usually at bedtime with a snack, unless directed otherwise.

If you forget a dose:
Take as soon as you remember.

What drug does:
Acts on smooth muscles of intestine wall to cause vigorous bowel movement.

Time lapse before drug works:
6 to 10 hours.

Don't take with:
Don't take within 2 hours of taking another medicine. Laxative interferes with medicine absorption.




Sennoside 10% Dry Powder USP & BP

Sennoside 10% Dry Powder USP & BP

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Item Code: 215

Offering Senna Dry Extract.

  • Senna dry extract is biggest product commercially for us.
  • We have dedicated plant for production of Senna Extract, capacity to produce 4 MT Sennosides per Month
  • Senna leaf extracts standardized to 8%, 10%, 15%, 20% and 60% Calcium sennosides.

Active Pharmaceutical Ingredients:

  • Senna extract A&B 20%, 40% and 60% as per USP.
  • Senna extract A&B 20%, 40% and 60% as per BP.
  • Senna extract A&B 20%, 40% and 60% by HPLC
  • Sennoside 90% as per USP.
  • Leaf Powder contain more than 2% of Sennoside.


Raw Senna Herb

  • Leaves of Different size grade.
  • Pods.


Cassia Angustifolia ( Senna ) Extract.

Cassia Angustifolia ( Senna ) Extract.

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Item Code: 216

Active Ingredient : Calcium Sennosides 10%, Calcium Sennosides 20% & Calcium Sennosides 40%

Common Name : Senna, Indian Senna, Tinnervelly Senna, Cassia Senna

Chemical Constituents and Components : Main chemical components are anthraquinone glycosides, sennosides, rhein, aloe-amine, kaempferein, iso-rhein, kaempferol, isormamnetin, myricyl alcohol, mucilage and flavonoids.

Action :
Sennosides: 1. It specifically influences large intestinal motility and show purgative action. 2. It influences both colon motility as well as colon secretion. 3. It shows good intestinal mucosa tolerance. 4. It significantly decreases net water and Na+ absorption and enhanced net K+ secretion.

Curing Diseases : 1. It is used in the treatment of constipation and act as purgative and laxative.
2. It is useful in indigestion, loss of appetite and obesity.
3. It is useful in hepatomegaly, spleenomegaly, jaundice and anaemia.
4. It is also useful in acne, ringworm affection and for inflammatory skin conditions.

Research Information : Cassia angustifolia extract is uaed as enema after abdominal operation. It regulates disordered funtion of gastrointestional tract abdominal operations. (Ref. Wang, M., Yan, S. and Wang, J., Clinical and experimental study on using Cassia angustifolia extract as enema after abdominal operation, PubMed, 1998 Sep; 18(9): 540-2)

Possible Combinations : Cassia angustifolia + citrus reticulate (weight loss)



Senna Leaf Pe Powder 20%

Senna Leaf Pe Powder 20%

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Item Code: 217

Active Ingredient : Calcium Sennosides 10%, Calcium Sennosides 20% & Calcium Sennosides 40%

Common Name : Senna, Indian Senna, Tinnervelly Senna, Cassia Senna

Chemical Constituents and Components : Main chemical components are anthraquinone glycosides, sennosides, rhein, aloe-amine, kaempferein, iso-rhein, kaempferol, isormamnetin, myricyl alcohol, mucilage and flavonoids.

Action :
Sennosides: 1. It specifically influences large intestinal motility and show purgative action. 2. It influences both colon motility as well as colon secretion. 3. It shows good intestinal mucosa tolerance. 4. It significantly decreases net water and Na+ absorption and enhanced net K+ secretion.

Curing Diseases : 1. It is used in the treatment of constipation and act as purgative and laxative.
2. It is useful in indigestion, loss of appetite and obesity.
3. It is useful in hepatomegaly, spleenomegaly, jaundice and anaemia.
4. It is also useful in acne, ringworm affection and for inflammatory skin conditions.

Research Information : Cassia angustifolia extract is uaed as enema after abdominal operation. It regulates disordered funtion of gastrointestional tract abdominal operations. (Ref. Wang, M., Yan, S. and Wang, J., Clinical and experimental study on using Cassia angustifolia extract as enema after abdominal operation, PubMed, 1998 Sep; 18(9): 540-2)

Possible Combinations : Cassia angustifolia + citrus reticulate (weight loss)



Sennoside USP 60%

Item Code: 219



Sennoside usp 60%


Active Ingredient : Calcium Sennosides 60%

Common Name : Senna, Indian Senna, Tinnervelly Senna, Cassia Senna

Chemical Constituents and Components : Main chemical components are anthraquinone glycosides, sennosides, rhein, aloe-amine, kaempferein, iso-rhein, kaempferol, isormamnetin, myricyl alcohol, mucilage and flavonoids.

Action :
Sennosides: 1. It specifically influences large intestinal motility and show purgative action. 2. It influences both colon motility as well as colon secretion. 3. It shows good intestinal mucosa tolerance. 4. It significantly decreases net water and Na+ absorption and enhanced net K+ secretion.

Curing Diseases : 1. It is used in the treatment of constipation and act as purgative and laxative.
2. It is useful in indigestion, loss of appetite and obesity.
3. It is useful in hepatomegaly, spleenomegaly, jaundice and anaemia.
4. It is also useful in acne, ringworm affection and for inflammatory skin conditions.

Research Information : Cassia angustifolia extract is uaed as enema after abdominal operation. It regulates disordered funtion of gastrointestional tract abdominal operations. (Ref. Wang, M., Yan, S. and Wang, J., Clinical and experimental study on using Cassia angustifolia extract as enema after abdominal operation, PubMed, 1998 Sep; 18(9): 540-2)

Possible Combinations : Cassia angustifolia + citrus reticulate (weight loss)



Sennosides High Titre

Item Code: 220
Sennoside high titre.
Active Ingredient : Calcium Sennosides 40% & 60%
Common Name : Senna, Indian Senna, Tinnervelly Senna, Cassia Senna
Chemical Constituents and Components : Main chemical components are anthraquinone glycosides, sennosides, rhein, aloe-amine, kaempferein, iso-rhein, kaempferol, isormamnetin, myricyl alcohol, mucilage and flavonoids.
Action :
Sennosides: 1. It specifically influences large intestinal motility and show purgative action. 2. It influences both colon motility as well as colon secretion. 3. It shows good intestinal mucosa tolerance. 4. It significantly decreases net water and Na+ absorption and enhanced net K+ secretion.
Curing Diseases : 1. It is used in the treatment of constipation and act as purgative and laxative.
2. It is useful in indigestion, loss of appetite and obesity.
3. It is useful in hepatomegaly, spleenomegaly, jaundice and anaemia.
4. It is also useful in acne, ringworm affection and for inflammatory skin conditions.
Research Information : Cassia angustifolia extract is uaed as enema after abdominal operation. It regulates disordered funtion of gastrointestional tract abdominal operations. (Ref. Wang, M., Yan, S. and Wang, J., Clinical and experimental study on using Cassia angustifolia extract as enema after abdominal operation, PubMed, 1998 Sep; 18(9): 540-2)
Possible Combinations : Cassia angustifolia + citrus reticulate (weight loss)

Sennoside B Calcium Salt.

Sennoside B Calcium Salt.

Yes! I am interested

Item Code: 221
Active - Sennoside B calcium salt.

Common Name : Senna, Indian Senna, Tinnervelly Senna, Cassia Senna
Chemical Constituents and Components : Main chemical components are anthraquinone glycosides, sennosides, rhein, aloe-amine, kaempferein, iso-rhein, kaempferol, isormamnetin, myricyl alcohol, mucilage and flavonoids.
Action :
Sennosides: 1. It specifically influences large intestinal motility and show purgative action. 2. It influences both colon motility as well as colon secretion. 3. It shows good intestinal mucosa tolerance. 4. It significantly decreases net water and Na+ absorption and enhanced net K+ secretion.
Curing Diseases : 1. It is used in the treatment of constipation and act as purgative and laxative.
2. It is useful in indigestion, loss of appetite and obesity.
3. It is useful in hepatomegaly, spleenomegaly, jaundice and anaemia.
4. It is also useful in acne, ringworm affection and for inflammatory skin conditions.
Research Information : Cassia angustifolia extract is uaed as enema after abdominal operation. It regulates disordered funtion of gastrointestional tract abdominal operations. (Ref. Wang, M., Yan, S. and Wang, J., Clinical and experimental study on using Cassia angustifolia extract as enema after abdominal operation, PubMed, 1998 Sep; 18(9): 540-2)
Possible Combinations : Cassia angustifolia + citrus reticulate (weight loss)


Senna Extract

Item Code: 401
Senna extract main product of vijay herbal & phyto chemicals.

Monthly production is 4000 kg.

All type of Sennoside.

Quality Control of Sennoside.

Item Code: 107
Sennosides as calcium salts are assayed as Total hydroxy anthracene glucosides estimated as Sennoside B. As per BP, E (1%,1cm) value of 240 or 200 for color development at 515nm and 500nm respectively) is used. USP employs spectroflurometric method necessitating the use of standard every time. There is an increased tendency nowadays to use HPLC method declaring Sennosides A + B. A rapid and useful method based on the BP is popularly used all over the world.

Chemistry, Isolation And Constituents

Chemistry, Isolation and Constituents

1. Isolation of a new aloe-emodin dianthrone diglucoside from senna and its potentiating effect on the purgative activity ofsennoside A in mice. Nakajima K; Yamauchi K; Kuwano S, J Pharm Pharmacol; VOL 37, ISS 10, 1985, P703-6 

 

2. Senna—an old drug in modern research. Lemli J,  Pharmacology, 36 Suppl 1(-HD-):3-6 1988

 

3. Isolation and structural definition of a new sennoside from Cassia senna L. (author’s transl), Christ B ; P¨oppinghaus T ; Wirtz-Peitz F ,Arzneimittelforschung, 28(2):225-31 1978

 

4. The effect of different storage conditions on the chemical stability, laxative effect and acute toxicity of sennosidesolutions. Lainonen H ; Marvola M ; Hietala P ; Parviainen T Pharmacol Toxicol; VOL 63, ISS 1, 1988, P37-41

 

5. The senna drug and its chemistry. Franz G, Pharmacology, 47 Suppl 1(-HD-):2-6 1993 Oct 

Pharmacology & Toxicology

Pharmacology & Toxicology

 

1.Senna-containing laxatives: excretion in the breast milk? Faber P; Strenge-Hesse A, Geburtshilfe Frauenheilkd 1989 Nov;49(11):958-6

 

 

2.Two-year carcinogenicity study with sennosides in the rat: emphasis on gastro-intestinal alterations. Lyd’en-Sokolowski A; Nilsson A; Sioberrg P, Pharmacology; VOL 47 Suppl 1, 1993, P209-15

 

 

3. Acute hemorrhagic colitis following administration ofsennosides A and B (letter), Villand J, Presse Med, 14(2):104-5 1985 Jan 19

 

 

4. Influence of a highly purified senna extract on colonic epithelium. van Gorkom BA; Karrenbeld A; van Der Sluis T;  Koudstaal J; de Vries EG; Kleibeuker JH, Digestion, 61(2):113-20 2000

 

 

5. Analytics of senna drugs with regard to the toxicological discussion of anthranoids., Grimminger W; Witthohn K, Pharmacology, 47 Suppl 1(-HD-):98-109 1993 Oct

 

 

6. Genotoxicity of sennosides on the bone marrow cells of mice. Mukhopadhyay MJ; Saha A; Dutta A; De B;Mukherjee A, Food Chem Toxicol 36(11):937-40 1998 Nov

 

 

7. Sennosides and human colonic motility. Staumont G; Frexinos J; Fioramonti J; Bu’eno L Pharmacology, 36 Suppl 1 (-HD-):49-56 1988

 

 

8. Long-term mucosal alterations by sennosides and related compounds. Dufour P; Gendre P Pharmacology 36 Suppl 1(-HD-):194-202 1988

 

 

9. Laxative potency and acute toxicity of some anthraquinone derivatives, senna extracts and fractions of senna extracts. Hietala P; Marvola M; Parviainen T; Laininen H, Pharmacol Toxicol, 61(2):153-6 1987 Aug

 

 

10. Toxic effects of sennosides in laboratory animals and in vitro. Mengs U, Pharmacology, 36 Suppl 1(-HD-):180-7 1988

 

 

11. Review article: anthranoid laxatives and their potential carcinogenic effects. van Gorkom BA ; de Vries EG ; Karrenbeld A ; Kleibeuker JH, Aliment Pharmacol Ther, 13(4):443-52 1999 Apr

 

 

 


Historical Or Traditional Use

Historical or traditional use (may or may not be supported by scientific studies): People in northern Africa and southwestern Asia have used senna as a laxative for centuries. It was considered a “cleansing” herb because of its cathartic effect. In addition, the leaves were sometimes made into a paste and applied to various skin diseases. Ringworm and acne were both treated in this way.

Medical uses : [1]
 Besides being a laxative, senna is used as a febrifuge, in splenic enlargements, anaemia, typhoid, cholera, biliousness, jaundice, gout, rheumatism, tumours, foul breath and bronchitis, and probably in leprosy. It is employed in the treatment of amoebic dysentery as an anthelmintic and as a mild liver stimulant. Leaves are astringent, bitter, sweet, acrid, thermogenic, catharitic, depurative, liver tonic, anthelmintic, cholagogue, expectorant, ferbifuge. Usefull in constipation, abdominal disordes, leprosy, skin disorders, leucoderma, splenomegaly, hepatomegaly, dyspepsia, cough, and bronchitis.

Chemistry and Pharmacology
Pharmacology [2]: 
Senna leaves and pods have been shown to have laxative activity. It is usefull in habitual constipation. Pharmacological investigations show that sennosides A and B account for the entire activity of the senna leaves and pods. [3]  Leaves contain glycosides, sennoside A, B, C & D. Two naphthalene glycosides have been isolated from leaves and pods.

Active constituents: Senna contains anthraquinone glycosides known as sennosides. These molecules are converted by the normal bacteria in the colon into rhein-anthrone, which in turn has two effects. It first stimulates colon activity and thus speeds bowel movements. Second, it increases fluid secretion by the colon.[4]

Together, these actions work to get a sluggish colon functional again. Several controlled studies have confirmed the benefit of senna in treating constipation.[5]

Constipation induced by drugs such as the anti-diarrhea medicine loperamide (Imodium®) has also been shown to be improved by senna in a clinical trial.[6]

Citations

[1] a The wealth of India, P.I.D., C.S.I.R., New Delhi (CD ROM Version). b Orient Longman, Indian Medical Plants. 1993; 2 : 23.)

[2] a. Grote et al., J Am. Pharm. Assoc. 1951; 40(52);3. b. Fairbairn & Michaels, "Vegetable Purgatives - Part III ")

[3] a. Tanaka, H. et al., Chem. Pharm Bull., 1982; 30 : 5; b. Lemli, J et al., Planta Medica. 1981; 43:11)

[4] Leng-Peschlow E. Dual effect of orally administered sennosides on large intestinal transit and fluid absorption in the rat. J Pharm Pharmacol 1986;38:606–10.)

[5] a.Passmore AP, Davies KW, Flanagan PG, et al. A comparison of Agiolax and Lactulose in elderly patients with chronic constipation. Pharmacol 1993;47(suppl 1):249–52.  b.Kinnunen O, Winblad I, Koistinen P, Salokannel J. Safety and efficacy of a bulk laxative containing senna versus lactulose in the treatment of chronic constipation in geriatric patients.Pharmacol 1993;47(suppl 1):253–5.)

[6] Ewe K, Ueberschaer B, Press AG. Influence of senna, fibre, and fibre+senna on colonic transit in loperamide-induced constipation. Pharmacol 1993;47(suppl 1):242–8


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